Berriew will face a testing trip to Wrexham outfit Plas Madoc in the last 16 of the FAW Trophy.
The Rhiw-siders eased past Rhydymwyn on Saturday thanks to a 2-0 victory at Talbot Field.
Division One Welsh National League outfit Plas Madoc have already knocked out higher level opposition in St Asaph City and Mynydd Llandegai from this season's competition.
Four Crosses will travel to Gwynedd League side Bodedern Athletic following their 3-1 victory over last season's finalists Rhos Aelwyd, while Cefn Albion will enjoy home advantage against Bow Street.
Draw in full:
Bodedern Athletic v Four Crosses
Cefn Albion v Bow Street
Corwen v Pwllheli
Grange Albion v Penydarren BGC
Llanrug United v Llangefni Town
Plas Madoc v Berriew
Pontardawe Town v Swansea University
STM Sports v Ynysddu Welfare/Ynyshir Albion
Ties to be played on Saturday, January 12
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